Bos taurus Gene: F13A1 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-636530.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | F13A1 | ||||||||||
Gene Name | Coagulation factor XIII A chain | ||||||||||
Synonyms | |||||||||||
Species | Bos taurus | ||||||||||
Ensembl Gene | ENSBTAG00000007268 | ||||||||||
Encoded Proteins |
Coagulation factor XIII A chain
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124491:
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 23:48633936-48776698 | ||||||||||
Strand | Forward strand | ||||||||||
Band | |||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||
NETPATH | |||||||||||
REACTOME |
Platelet degranulation pathway
Common Pathway pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
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KEGG | |||||||||||
INOH | |||||||||||
PID NCI | |||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||
NETPATH | |||||||||||
REACTOME |
Common Pathway pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet activation, signaling and aggregation pathway
Hemostasis pathway
Platelet degranulation pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Response to elevated platelet cytosolic Ca2+ pathway
Common Pathway pathway
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KEGG |
Complement and coagulation cascades pathway
Complement and coagulation cascades pathway
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INOH | |||||||||||
PID NCI |
Beta1 integrin cell surface interactions
Alpha9 beta1 integrin signaling events
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Cross-References | |||||||||||
SwissProt | P12260 | ||||||||||
TrEMBL | F1MW44 Q27982 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 617881 | ||||||||||
UniGene | Bt.19195 | ||||||||||
RefSeq | NM_001167894 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | BT025350 DAAA02055840 DAAA02055841 DAAA02055842 DAAA02055843 DAAA02055844 DAAA02055845 U13392 | ||||||||||
GenPept | AAB60265 ABF57306 | ||||||||||
RNA Seq Atlas | 617881 | ||||||||||