InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.62162

Summary

InnateDB Gene

IDBG-636736.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.62162

Gene Name

Abelson tyrosine-protein kinase 2

Synonyms

ABLL

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015026

Encoded Proteins

IDBP-688697

tyrosine-protein kinase ABL2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143322:
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:61897894-61992970

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020006

ENSBTAP00000020006

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030145	manganese ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007015	actin filament organization
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0051017	actin filament bundle assembly
GO:0051353	positive regulation of oxidoreductase activity
GO:0071300	cellular response to retinoic acid