InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RAG2

Summary

InnateDB Gene

IDBG-636766.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAG2

Gene Name

V(D)J recombination-activating protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000031309

Encoded Proteins

IDBP-688722

V(D)J recombination-activating protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175097:
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:67841773-67849540

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000039656

ENSBTAP00000039446

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding
GO:0035091	phosphatidylinositol binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0002326	B cell lineage commitment
GO:0002331	pre-B cell allelic exclusion
GO:0002358	B cell homeostatic proliferation
GO:0002360	T cell lineage commitment
GO:0006310	DNA recombination
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0033077	T cell differentiation in thymus
GO:0033151	V(D)J recombination
GO:0046622	positive regulation of organ growth

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000175097

View Gene Order

ENSMUSG00000032864

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05340

Primary immunodeficiency pathway

mmu05340

Primary immunodeficiency pathway

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.88102

RefSeq

NM_001082469 XM_005216393

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas