Version 5.4
Bos taurus Gene: MECOM
Summary
InnateDB Gene IDBG-636773.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MECOM
Gene Name Uncharacterized protein
Synonyms EVI1
Species Bos taurus
Ensembl Gene ENSBTAG00000005871
Encoded Proteins
IDBP-688764
MDS1 and EVI1 complex locus
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085276:
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:99090972-99143289
Strand Forward strand
Band
Transcripts
ENSBTAT00000007717 ENSBTAP00000007717
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0043069 negative regulation of programmed cell death
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046329 negative regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:0071425 hematopoietic stem cell proliferation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000085276
View Gene Order
ENSMUSG00000027684
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
mmu04010
MAPK signaling pathway pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BMZ2
UniProt Splice Variant
Entrez Gene 532209
UniGene Bt.105660 Bt.106181
RefSeq XM_003581740 XM_003581741 XM_003585683 XM_003585684 XM_005195927 XM_005195928 XM_005195931 XM_005195933 XM_005195934 XM_005201766 XM_005201767 XM_005201770 XM_005201772 XM_005201773
HUGO HGNC:3498
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02002232
GenPept
RNA Seq Atlas 532209

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca