Bos taurus Gene: ASPN
Summary
InnateDB Gene IDBG-636796.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASPN
Gene Name Asporin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011847
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106819:
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:85499333-85524670
Strand Reverse strand
Band
Transcripts
ENSBTAT00000035046 ENSBTAP00000034926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0030282 bone mineralization
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0070171 negative regulation of tooth mineralization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Extracellular matrix organization pathway
ECM proteoglycans pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3ZBN5
TrEMBL
UniProt Splice Variant
Entrez Gene 507990
UniGene Bt.111850 Bt.45145
RefSeq NM_001034309
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103199
GenPept AAI03200
RNA Seq Atlas 507990