Version 5.4
Bos taurus Gene: GMDS
Summary
InnateDB Gene IDBG-636823.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMDS
Gene Name GDP-mannose 4,6 dehydratase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012058
Encoded Proteins
IDBP-688792
GDP-mannose 4,6 dehydratase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112699:
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:51117008-51453402
Strand Forward strand
Band
Transcripts
ENSBTAT00000015992 ENSBTAP00000015992
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008446 GDP-mannose 4,6-dehydratase activity
GO:0050662 coenzyme binding
GO:0070401 NADP+ binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0019673 GDP-mannose metabolic process
GO:0042351 'de novo' GDP-L-fucose biosynthetic process
GO:0044237 cellular metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000112699
View Gene Order
ENSMUSG00000038372
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00051
Fructose and mannose metabolism pathway
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
mmu00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MBF1 Q3ZBY8
UniProt Splice Variant
Entrez Gene 617688
UniGene Bt.15923
RefSeq NM_001080331
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103030 DAAA02055917 DAAA02055918 DAAA02055919 DAAA02055920 DAAA02055921 DAAA02055922
GenPept AAI03031
RNA Seq Atlas 617688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca