InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CRY2

Summary

InnateDB Gene

IDBG-636948.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRY2

Gene Name

Uncharacterized protein

Synonyms

CRY2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021223

Encoded Proteins

IDBP-688989

cryptochrome 2 (photolyase-like)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:76753525-76790450

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028277

ENSBTAP00000028277

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000989	transcription factor binding transcription factor activity
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0003913	DNA photolyase activity
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0035257	nuclear hormone receptor binding
GO:0043130	ubiquitin binding
GO:0071949	FAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006281	DNA repair
GO:0006606	protein import into nucleus
GO:0007623	circadian rhythm
GO:0019915	lipid storage
GO:0032515	negative regulation of phosphoprotein phosphatase activity
GO:0032868	response to insulin
GO:0032922	circadian regulation of gene expression
GO:0042593	glucose homeostasis
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0045892	negative regulation of transcription, DNA-templated
GO:2000118	regulation of sodium-dependent phosphate transport
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway
GO:2000850	negative regulation of glucocorticoid secretion