Version 5.4
Bos taurus Gene: ZYX
Summary
InnateDB Gene IDBG-636950.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZYX
Gene Name zyxin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017970
Encoded Proteins
IDBP-688927
zyxin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159840:
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:107598856-107607834
Strand Forward strand
Band
Transcripts
ENSBTAT00000023912 ENSBTAP00000023912
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Predicted by orthology
Total 57 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005913 cell-cell adherens junction
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000159840
View Gene Order
ENSMUSG00000029860
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04510
Focal adhesion pathway
mmu04510
Focal adhesion pathway
INOH
PID NCI
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
ilk_pathway
Integrin-linked kinase signaling
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.65076
RefSeq NM_001078101 XM_005205889 XM_005205890
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca