Version 5.4
Bos taurus Gene: GADD45G
Summary
InnateDB Gene IDBG-637039.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GADD45G
Gene Name Growth arrest and DNA damage-inducible protein GADD45 gamma
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003033
Encoded Proteins
IDBP-689013
Growth arrest and DNA damage-inducible protein GADD45 gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130222:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:90017453-90018996
Strand Reverse strand
Band
Transcripts
ENSBTAT00000003943 ENSBTAP00000003943
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000185 activation of MAPKKK activity
GO:0000186 activation of MAPKK activity
GO:0006469 negative regulation of protein kinase activity
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:1900745 positive regulation of p38MAPK cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000130222
View Gene Order
ENSMUSG00000021453
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04110
Cell cycle pathway
hsa04010
MAPK signaling pathway pathway
hsa04115
p53 signaling pathway pathway
mmu04115
p53 signaling pathway pathway
mmu04110
Cell cycle pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
il12_2pathway
IL12-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.30720
RefSeq NM_001045901
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca