Version 5.4
Bos taurus Gene: HADHB
Summary
InnateDB Gene IDBG-637083.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HADHB
Gene Name Trifunctional enzyme subunit beta, mitochondrial 3-ketoacyl-CoA thiolase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010083
Encoded Proteins
IDBP-689080
Trifunctional enzyme subunit beta, mitochondrial3-ketoacyl-CoA thiolase
IDBP-689083
Trifunctional enzyme subunit beta, mitochondrial3-ketoacyl-CoA thiolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138029:
This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in this gene result in trifunctional protein deficiency. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Alternatively spliced transcript variants have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:73215424-73246167
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013310 ENSBTAP00000013310
ENSBTAT00000063404 ENSBTAP00000055705
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0005515 protein binding
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0042645 mitochondrial nucleoid
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138029
View Gene Order
ENSMUSG00000059447
View Gene Order
Pathways
NETPATH
REACTOME
REACT_214604
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
REACT_202421
Glycerophospholipid biosynthesis pathway
REACT_208669
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_226164
Acyl chain remodeling of CL pathway
REACT_211406
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_225673
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_221200
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_201892
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_219139
Metabolism pathway
REACT_218329
Phospholipid metabolism pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_220229
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_202075
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121006
Acyl chain remodeling of CL pathway
REACT_1887
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_2108
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
REACT_2025
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
REACT_735
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_1697
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_1708
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_1541
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_111217
Metabolism pathway
REACT_199034
Acyl chain remodeling of CL pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_233858
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_237597
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_188937
Metabolism pathway
REACT_236353
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_261839
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_257646
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_256910
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_239107
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
REACT_251878
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00071
Fatty acid degradation pathway
hsa00062
Fatty acid elongation pathway
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00062
Fatty acid elongation pathway
mmu00071
Fatty acid degradation pathway
INOH
INOH website
Valine Leucine Isoleucine degradation pathway
PID NCI
Cross-References
SwissProt O46629
TrEMBL
UniProt Splice Variant
Entrez Gene 281811
UniGene Bt.52915
RefSeq NM_174336 XM_005212930 XM_005212931
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ003066 BC102638
GenPept AAI02639 CAA05840
RNA Seq Atlas 281811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca