InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DNMT3A

Summary

InnateDB Gene

IDBG-637166.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNMT3A

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021143

Encoded Proteins

IDBP-689202

DNA (cytosine-5-)-methyltransferase 3 alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119772:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:74030425-74059688

Strand

Forward strand

Band

Transcripts

ENSBTAT00000032936

ENSBTAP00000032863

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006346	methylation-dependent chromatin silencing
GO:0006349	regulation of gene expression by genetic imprinting
GO:0007283	spermatogenesis
GO:0043045	DNA methylation involved in embryo development
GO:0043046	DNA methylation involved in gamete generation
GO:0044027	hypermethylation of CpG island
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000791	euchromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005720	nuclear heterochromatin
GO:0005737	cytoplasm
GO:0016363	nuclear matrix