Version 5.4
Bos taurus Gene: MAP4K1
Summary
InnateDB Gene IDBG-637177.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP4K1
Gene Name mitogen-activated protein kinase kinase kinase kinase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021145
Encoded Proteins
IDBP-689178
mitogen-activated protein kinase kinase kinase kinase 1
IDBP-689181
mitogen-activated protein kinase kinase kinase kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104814:
Gene Information
Type Protein coding
Genomic Location Chromosome 18:48633598-48647723
Strand Reverse strand
Band
Transcripts
ENSBTAT00000028180 ENSBTAP00000028180
ENSBTAT00000032204 ENSBTAP00000032141
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008349 MAP kinase kinase kinase kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0000185 activation of MAPKKK activity
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0008283 cell proliferation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000104814
View Gene Order
ENSMUSG00000037337
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
tcrjnkpathway
JNK signaling in the CD4+ TCR pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.59664
RefSeq NM_001075825
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca