Version 5.4
| Bos taurus Gene: MAP2K4 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-637253.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | MAP2K4 | ||||||||||||||||
| Gene Name | dual specificity mitogen-activated protein kinase kinase 4 | ||||||||||||||||
| Synonyms | |||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Gene | ENSBTAG00000012103 | ||||||||||||||||
| Encoded Proteins |
dual specificity mitogen-activated protein kinase kinase 4
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| Protein Structure | |||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||
| Summary |
[Homo sapiens] Activates JNK proteins
[Homo sapiens] Activated by MAP3K 2,3,4,5 (MEKK 2,3,4,5)
[Homo sapiens] Activated by MAP3K 2,3,4,5 (MEKK 2,3,4,5)
[Homo sapiens] Activated by MAP3K 2,3,4,5 (MEKK 2,3,4,5)
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| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065559:
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008] This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 19:31284737-31363093 | ||||||||||||||||
| Strand | Forward strand | ||||||||||||||||
| Band | |||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH |
Wnt pathway
TNFalpha pathway
IL1 pathway
IL6 pathway
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| REACTOME |
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Interleukin-1 signaling pathway
Cellular responses to stress pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Uptake and actions of bacterial toxins pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Cellular Senescence pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
Uptake and function of anthrax toxins pathway
Disease pathway
FCERI mediated MAPK activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Oxidative Stress Induced Senescence pathway
Cellular responses to stress pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
MyD88 dependent cascade initiated on endosome pathway
Activated TLR4 signalling pathway
Interleukin-1 signaling pathway
MyD88-independent cascade pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
FCERI mediated MAPK activation pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
GnRH signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
ErbB signaling pathway pathway
MAPK signaling pathway pathway
Toll-like receptor signaling pathway pathway
Chagas disease (American trypanosomiasis) pathway
ErbB signaling pathway pathway
Toll-like receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
EGF signaling pathway pathway
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
TGF-beta signaling pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
EGF signaling pathway pathway
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
TGF-beta signaling pathway
PDGF signaling pathway pathway
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| PID NCI |
Nephrin/Neph1 signaling in the kidney podocyte
CD40/CD40L signaling
Ceramide signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Cellular roles of Anthrax toxin
VEGFR3 signaling in lymphatic endothelium
TRAIL signaling pathway
ErbB1 downstream signaling
Signaling events mediated by focal adhesion kinase
RAC1 signaling pathway
Ephrin B reverse signaling
JNK signaling in the CD4+ TCR pathway
CDC42 signaling events
Regulation of p38-alpha and p38-beta
RhoA signaling pathway
Regulation of Androgen receptor activity
Fc-epsilon receptor I signaling in mast cells
IL6-mediated signaling events
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| Cross-References | |||||||||||||||||
| SwissProt | |||||||||||||||||
| TrEMBL | A5PJP8 | ||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 526469 | ||||||||||||||||
| UniGene | Bt.23717 | ||||||||||||||||
| RefSeq | NM_001099038 XM_005220369 XM_005220370 | ||||||||||||||||
| HUGO | |||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | BC142195 DAAA02048884 DAAA02048885 DAAA02048886 | ||||||||||||||||
| GenPept | AAI42196 | ||||||||||||||||
| RNA Seq Atlas | 526469 | ||||||||||||||||