InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.89249

Summary

InnateDB Gene

IDBG-637291.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.89249

Gene Name

ATP-binding cassette sub-family A member 1

Synonyms

ABC-1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020661

Encoded Proteins

IDBP-689298

ATP-binding cassette sub-family A member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20472936

[Homo sapiens] ABCA1 promotes the efflux of bacterial lipopolysaccharide (LPS) from macrophages and accelerates recovery from LPS-induced tolerance.

PMID 20650929

[Homo sapiens] ABCA1 in macrophages dampens inflammation by reducing MYD88-dependent TLR trafficking to lipid rafts, thus selectively reducing free cholesterol content in lipid rafts.

PMID 22955730

[Homo sapiens] ABCA1 deletion in the myeloid lineage enhances host immune response and clearance of Listeria monocytogenes. (Demonstrated in mice)

PMID 22955730

[Mus musculus] Abca1 deletion in the myeloid lineage enhances host immune response and clearance of Listeria monocytogenes.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165029:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier\'s disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:96274035-96390357

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000027538

ENSBTAP00000027538

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0008509	anion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0017127	cholesterol transporter activity
GO:0019905	syntaxin binding
GO:0031267	small GTPase binding
GO:0034185	apolipoprotein binding
GO:0034186	apolipoprotein A-I binding
GO:0034188	apolipoprotein A-I receptor activity
GO:0051117	ATPase binding

Biological Process

GO:0002790	peptide secretion
GO:0006200	ATP catabolic process
GO:0006497	protein lipidation
GO:0006911	phagocytosis, engulfment
GO:0007040	lysosome organization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008203	cholesterol metabolic process
GO:0010875	positive regulation of cholesterol efflux
GO:0016197	endosomal transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032367	intracellular cholesterol transport
GO:0032489	regulation of Cdc42 protein signal transduction
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034380	high-density lipoprotein particle assembly
GO:0034616	response to laminar fluid shear stress
GO:0038027	apolipoprotein A-I-mediated signaling pathway
GO:0042157	lipoprotein metabolic process
GO:0042158	lipoprotein biosynthetic process
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0045332	phospholipid translocation
GO:0050702	interleukin-1 beta secretion
GO:0055091	phospholipid homeostasis
GO:0055098	response to low-density lipoprotein particle stimulus
GO:0060155	platelet dense granule organization
GO:0071222	cellular response to lipopolysaccharide
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0030139	endocytic vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0045121	membrane raft
GO:0045335	phagocytic vesicle
GO:0048471	perinuclear region of cytoplasm