Version 5.4
Bos taurus Gene: SMCX
Summary
InnateDB Gene IDBG-637352.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMCX
Gene Name lysine-specific demethylase 5C
Synonyms JARID1C; SMCX
Species Bos taurus
Ensembl Gene ENSBTAG00000014943
Encoded Proteins
IDBP-689369
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126012:
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:96041772-96072571
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019893 ENSBTAP00000019893
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032453 histone demethylase activity (H3-K4 specific)
GO:0046872 metal ion binding
Biological Process
GO:0034720 histone H3-K4 demethylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000126012
View Gene Order
ENSMUSG00000025332
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_218274
Chromatin organization pathway
REACT_256030
HDMs demethylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MYV2 Q9BDZ5 Q9XSG1
UniProt Splice Variant
Entrez Gene 281490
UniGene Bt.8145
RefSeq NM_174185 XM_005228197 XM_005228198 XM_005228199 XM_005228200 XM_005228201
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF134848 AH007768 DAAA02073278
GenPept AAD34440 AAK27838
RNA Seq Atlas 281490

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca