Bos taurus Gene: SMC1A | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-637394.3 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | SMC1A | ||||||||||||||||||||||||||
Gene Name | Structural maintenance of chromosomes protein 1A | ||||||||||||||||||||||||||
Synonyms | SMC-1A; SMC1L1 | ||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000017761 | ||||||||||||||||||||||||||
Encoded Proteins |
Structural maintenance of chromosomes protein 1A
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072501:
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq, Jul 2008] Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome X:96218220-96252806 | ||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
S Phase pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing pathway
Cohesin Loading onto Chromatin pathway
Meiotic synapsis pathway
Mitotic Telophase/Cytokinesis pathway
M Phase pathway
Separation of Sister Chromatids pathway
Meiosis pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Anaphase pathway
Gene Expression pathway
Cell Cycle, Mitotic pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Cell Cycle pathway
Establishment of Sister Chromatid Cohesion pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
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KEGG | |||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Meiotic synapsis pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
Cohesin Loading onto Chromatin pathway
Mitotic Telophase/Cytokinesis pathway
Establishment of Sister Chromatid Cohesion pathway
mRNA Splicing - Major Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
S Phase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
mRNA Splicing pathway
Meiosis pathway
Gene Expression pathway
Mitotic Metaphase and Anaphase pathway
Meiotic Synapsis pathway
Mus musculus biological processes pathway
Cell Cycle, Mitotic pathway
Separation of Sister Chromatids pathway
mRNA Splicing pathway
Resolution of Sister Chromatid Cohesion pathway
Meiotic synapsis pathway
Cell Cycle pathway
M Phase pathway
Mitotic Telophase/Cytokinesis pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Prometaphase pathway
Cohesin Loading onto Chromatin pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
Establishment of Sister Chromatid Cohesion pathway
Meiosis pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Mitotic Anaphase pathway
S Phase pathway
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KEGG |
Cell cycle pathway
Oocyte meiosis pathway
Cell cycle pathway
Oocyte meiosis pathway
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INOH | |||||||||||||||||||||||||||
PID NCI |
ATM pathway
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
UniGene | Bt.109789 | ||||||||||||||||||||||||||
RefSeq | NM_174614 | ||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||