InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SARS2

Summary

InnateDB Gene

IDBG-637433.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SARS2

Gene Name

Serine--tRNA ligase, mitochondrial

Synonyms

SerRS

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001780

Encoded Proteins

IDBP-689451

Seryl-tRNA synthetase, mitochondrial

IDBP-689458

Seryl-tRNA synthetase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104835:
This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:48896564-48905610

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002334	ENSBTAP00000002334
ENSBTAT00000032066	ENSBTAP00000032008

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004828	serine-tRNA ligase activity
GO:0005524	ATP binding
GO:0016874	ligase activity

Biological Process

GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006434	seryl-tRNA aminoacylation
GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000104835

View Gene Order

ENSMUSG00000070699

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15302

Mitochondrial tRNA aminoacylation pathway

REACT_15482

tRNA Aminoacylation pathway

REACT_71

Gene Expression pathway

KEGG

hsa00970

Aminoacyl-tRNA biosynthesis pathway

mmu00970

Aminoacyl-tRNA biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

Q9N0F3

TrEMBL

G8JKV4 Q58CS4

UniProt Splice Variant

Entrez Gene

282060

UniGene

Bt.8850

RefSeq

NM_174457

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB029947 BC140548 BT021565 BT021873 BT021900 DAAA02047041

GenPept

AAI40549 AAX46412 AAX46720 AAX46747 BAA99556

RNA Seq Atlas

282060