Version 5.4
Bos taurus Gene: AKAP10
Summary
InnateDB Gene IDBG-637540.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP10
Gene Name A-kinase anchor protein 10, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003439
Encoded Proteins
IDBP-689567
A kinase anchor protein 10, mitochondrial
IDBP-689570
A kinase anchor protein 10, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21247892
[Homo sapiens] AKAP10 is required to induce PTGES2 in the synthesis of NO upon LPS stimulation, in addition AKAP10 also mediates the PTGES2-induced expression of cytokines IL10 and IL6 in alveolar macrophages. (Demonstrated in rat models)
PMID 21247892
[Mus musculus] Akap10 is required to induce Ptges2 in the synthesis of NO upon LPS stimulation, in addition Akap10 also mediates the Ptges2-induced expression of cytokines Il10 and Il6 in alveolar macrophages. (Demonstrated in rat models)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108599:
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:34343306-34386583
Strand Forward strand
Band
Transcripts
ENSBTAT00000053492 ENSBTAP00000048146
ENSBTAT00000043861 ENSBTAP00000041402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008104 protein localization
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000108599
View Gene Order
ENSMUSG00000047804
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.58017
RefSeq NM_001098024 XM_005220349
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca