InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PFKFB1

Summary

InnateDB Gene

IDBG-637557.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKFB1

Gene Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000172

Encoded Proteins

IDBP-689602

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158571:
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:97738494-97888649

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000198

ENSBTAP00000000198

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003873	6-phosphofructo-2-kinase activity
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006000	fructose metabolic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0008152	metabolic process
GO:0016311	dephosphorylation
GO:0046835	carbohydrate phosphorylation