Version 5.4
Bos taurus Gene: TPR
Summary
InnateDB Gene IDBG-637580.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPR
Gene Name nucleoprotein TPR
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011943
Encoded Proteins
IDBP-689786
translocated promoter region (to activated MET oncogene)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047410:
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5\' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:68886195-68949366
Strand Reverse strand
Band
Transcripts
ENSBTAT00000015848 ENSBTAP00000015848
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003682 chromatin binding
GO:0003729 mRNA binding
GO:0005487 nucleocytoplasmic transporter activity
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0031072 heat shock protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0051019 mitogen-activated protein kinase binding
GO:0070840 dynein complex binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000189 MAPK import into nucleus
GO:0006404 RNA import into nucleus
GO:0006405 RNA export from nucleus
GO:0006606 protein import into nucleus
GO:0006999 nuclear pore organization
GO:0007094 mitotic spindle assembly checkpoint
GO:0010965 regulation of mitotic sister chromatid separation
GO:0031453 positive regulation of heterochromatin assembly
GO:0031990 mRNA export from nucleus in response to heat stress
GO:0034605 cellular response to heat
GO:0035457 cellular response to interferon-alpha
GO:0042307 positive regulation of protein import into nucleus
GO:0045947 negative regulation of translational initiation
GO:0046832 negative regulation of RNA export from nucleus
GO:0070849 response to epidermal growth factor
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090316 positive regulation of intracellular protein transport
GO:1901673 regulation of spindle assembly involved in mitosis
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005868 cytoplasmic dynein complex
GO:0019898 extrinsic component of membrane
GO:0031965 nuclear membrane
GO:0034399 nuclear periphery
GO:0042405 nuclear inclusion body
GO:0044615 nuclear pore nuclear basket
GO:0072686 mitotic spindle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000047410
View Gene Order
ENSMUSG00000006005
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_6804
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_212
Glucose transport pathway
REACT_9441
Hexose transport pathway
REACT_9395
Nuclear import of Rev protein pathway
REACT_7991
Vpr-mediated nuclear import of PICs pathway
REACT_6190
Rev-mediated nuclear export of HIV RNA pathway
REACT_6354
Viral Messenger RNA Synthesis pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6167
Influenza Infection pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_25229
Interferon Signaling pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_6256
HIV Life Cycle pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_6185
HIV Infection pathway
REACT_6145
Influenza Life Cycle pathway
REACT_111217
Metabolism pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_6916
Interactions of Rev with host cellular proteins pathway
REACT_71
Gene Expression pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_12472
Regulatory RNA pathways pathway
REACT_196648
Nuclear Envelope Breakdown pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_196650
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_204192
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_188804
Cell Cycle pathway
REACT_188937
Metabolism pathway
REACT_241408
M Phase pathway
REACT_270446
Transcriptional regulation by small RNAs pathway
REACT_253543
Glucose transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_240125
Hexose transport pathway
REACT_203949
Glycogen storage diseases pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_250557
Mitotic Prophase pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
hsa05216
Thyroid cancer pathway
hsa05200
Pathways in cancer pathway
hsa03013
RNA transport pathway
mmu05216
Thyroid cancer pathway
mmu05200
Pathways in cancer pathway
mmu03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BF47
UniProt Splice Variant
Entrez Gene 507869
UniGene Bt.1386
RefSeq NM_001205623 XM_005217337
HUGO HGNC:12017
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02043627
GenPept
RNA Seq Atlas 507869

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca