Homo sapiens Gene: GPER
Summary
InnateDB Gene IDBG-6376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPER
Gene Name G protein-coupled estrogen receptor 1
Synonyms CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER; GPR30; LERGU; LERGU2; LyGPR; mER;
Species Homo sapiens
Ensembl Gene ENSG00000164850
Encoded Proteins
G protein-coupled estrogen receptor 1
G protein-coupled estrogen receptor 1
G protein-coupled estrogen receptor 1
G protein-coupled estrogen receptor 1
G protein-coupled estrogen receptor 1
G protein-coupled estrogen receptor 1
G protein-coupled estrogen receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:1082208-1093815
Strand Forward strand
Band p22.3
Transcripts
ENST00000297469 ENSP00000297469
ENST00000397092 ENSP00000380281
ENST00000397088 ENSP00000380277
ENST00000401670 ENSP00000385151
ENST00000413368 ENSP00000410487
ENST00000619052 ENSP00000483756
ENST00000617001 ENSP00000479553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004930 G-protein coupled receptor activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0017082 mineralocorticoid receptor activity
GO:0030284 estrogen receptor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0001956 positive regulation of neurotransmitter secretion
GO:0002695 negative regulation of leukocyte activation
GO:0006954 inflammatory response
GO:0007049 cell cycle
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019228 neuronal action potential
GO:0030263 apoptotic chromosome condensation
GO:0030264 nuclear fragmentation involved in apoptotic nuclear change
GO:0030335 positive regulation of cell migration
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031959 mineralocorticoid receptor signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032962 positive regulation of inositol trisphosphate biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response
GO:0045599 negative regulation of fat cell differentiation
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045909 positive regulation of vasodilation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050728 negative regulation of inflammatory response
GO:0050769 positive regulation of neurogenesis
GO:0051053 negative regulation of DNA metabolic process
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 cytosolic calcium ion homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070474 positive regulation of uterine smooth muscle contraction
GO:0071157 negative regulation of cell cycle arrest
GO:0071333 cellular response to glucose stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0071375 cellular response to peptide hormone stimulus
GO:0071389 cellular response to mineralocorticoid stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031966 mitochondrial membrane
GO:0032591 dendritic spine membrane
GO:0042734 presynaptic membrane
GO:0043198 dendritic shaft
GO:0043679 axon terminus
GO:0044327 dendritic spine head
GO:0045095 keratin filament
GO:0048471 perinuclear region of cytoplasm
GO:0048786 presynaptic active zone
GO:0055037 recycling endosome
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9J3W2 Q63ZY2 Q7Z7A9
UniProt Splice Variant
Entrez Gene 2852
UniGene
RefSeq NM_001505 NM_001098201 NM_001039966
HUGO HGNC:4485
OMIM 601805
CCDS CCDS5322
HPRD
IMGT
EMBL AC091729 AY265807 BC082766
GenPept AAH82766 AAP40320
RNA Seq Atlas 2852