Homo sapiens Gene: SI
Summary
InnateDB Gene IDBG-63763.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SI
Gene Name sucrase-isomaltase (alpha-glucosidase)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000090402
Encoded Proteins
sucrase-isomaltase (alpha-glucosidase)
sucrase-isomaltase (alpha-glucosidase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:164978898-165078495
Strand Reverse strand
Band q26.1
Transcripts
ENST00000264382 ENSP00000264382
ENST00000476593 ENSP00000419450
ENST00000463607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004558 alpha-glucosidase activity
GO:0004574 oligo-1,6-glucosidase activity
GO:0004575 sucrose alpha-glucosidase activity
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0044245 polysaccharide digestion
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
Disease pathway
Digestion of dietary carbohydrate pathway
Glycogen storage diseases pathway
KEGG
Galactose metabolism pathway
Starch and sucrose metabolism pathway
Carbohydrate digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.429596 Hs.627342
RefSeq NM_001041
HUGO
OMIM
CCDS CCDS3196
HPRD 01962
IMGT
EMBL
GenPept
RNA Seq Atlas