Version 5.4
Bos taurus Gene: TXN
Summary
InnateDB Gene IDBG-637688.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXN
Gene Name Thioredoxin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002953
Encoded Proteins
IDBP-689716
Thioredoxin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136810:
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:101484812-101492588
Strand Reverse strand
Band
Transcripts
ENSBTAT00000044356 ENSBTAP00000041860
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015035 protein disulfide oxidoreductase activity
GO:0015037 peptide disulfide oxidoreductase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006662 glycerol ether metabolic process
GO:0009314 response to radiation
GO:0033158 regulation of protein import into nucleus, translocation
GO:0043388 positive regulation of DNA binding
GO:0045454 cell redox homeostasis
GO:0046826 negative regulation of protein export from nucleus
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000136810
View Gene Order
ENSMUSG00000028367
View Gene Order
Pathways
NETPATH
REACTOME
REACT_209119
Inflammasomes pathway
REACT_218317
The NLRP3 inflammasome pathway
REACT_206069
Cellular responses to stress pathway
REACT_213138
Immune System pathway
REACT_204534
Detoxification of Reactive Oxygen Species pathway
REACT_215025
Cellular Senescence pathway
REACT_210940
Metabolism of nucleotides pathway
REACT_219947
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_225657
Oxidative Stress Induced Senescence pathway
REACT_219139
Metabolism pathway
REACT_216714
Innate Immune System pathway
REACT_223832
Synthesis and interconversion of nucleotide di- and triphosphates pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_75808
The NLRP3 inflammasome pathway
REACT_75900
Inflammasomes pathway
REACT_21330
Synthesis and interconversion of nucleotide di- and triphosphates pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_120956
Cellular responses to stress pathway
REACT_6802
Innate Immune System pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_111217
Metabolism pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_238368
Synthesis and interconversion of nucleotide di- and triphosphates pathway
REACT_239142
Innate Immune System pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_188957
Cellular responses to stress pathway
REACT_189141
Detoxification of Reactive Oxygen Species pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_188820
Cellular Senescence pathway
REACT_198644
The NLRP3 inflammasome pathway
REACT_198656
Inflammasomes pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
INOH
PID NCI
tnfpathway
TNF receptor signaling pathway
ptp1bpathway
Signaling events mediated by PTP1B
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt O97680
TrEMBL G8JKZ8
UniProt Splice Variant
Entrez Gene 280950
UniGene Bt.231
RefSeq NM_173968
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF104105 BC103415 BC120457 DAAA02024483 DAAA02024484
GenPept AAC83380 AAI03416 AAI20458
RNA Seq Atlas 280950

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca