Version 5.4
Bos taurus Gene: P2RX6
Summary
InnateDB Gene IDBG-637709.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX6
Gene Name P2X purinoceptor
Synonyms P2RXL1
Species Bos taurus
Ensembl Gene ENSBTAG00000019244
Encoded Proteins
IDBP-689818
purinergic receptor P2X, ligand-gated ion channel, 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099957:
The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74356168-74364530
Strand Forward strand
Band
Transcripts
ENSBTAT00000025626 ENSBTAP00000025626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005524 ATP binding
GO:0042802 identical protein binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0034220 ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0051260 protein homooligomerization
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000099957
View Gene Order
ENSMUSG00000022758
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1B742
UniProt Splice Variant
Entrez Gene 618262
UniGene Bt.110532
RefSeq XM_002694647 XM_870593
HUGO HGNC:8538
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045741
GenPept
RNA Seq Atlas 618262

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca