InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PLCE1

Summary

InnateDB Gene

IDBG-637752.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCE1

Gene Name

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018966

Encoded Proteins

IDBP-689841

phospholipase C, epsilon 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138193:
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:15372112-15701216

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025249

ENSBTAP00000025249

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0019899	enzyme binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016042	lipid catabolic process
GO:0032835	glomerulus development
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0045859	regulation of protein kinase activity
GO:0046578	regulation of Ras protein signal transduction