InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HELLS

Summary

InnateDB Gene

IDBG-637847.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HELLS

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005979

Encoded Proteins

IDBP-689887

helicase, lymphoid-specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119969:
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:15857421-15897465

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007848

ENSBTAP00000007848

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001655	urogenital system development
GO:0006306	DNA methylation
GO:0006342	chromatin silencing
GO:0006346	methylation-dependent chromatin silencing
GO:0007275	multicellular organismal development
GO:0010216	maintenance of DNA methylation
GO:0031508	centromeric heterochromatin assembly
GO:0043066	negative regulation of apoptotic process
GO:0046651	lymphocyte proliferation
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005721	centromeric heterochromatin

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000119969

View Gene Order

ENSMUSG00000025001

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

TrEMBL

E1BCV0

UniProt Splice Variant

Entrez Gene

540933

UniGene

Bt.111692 Bt.112211 Bt.62271

RefSeq

XM_002698391 XM_003584083

HUGO

HGNC:4861

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02058849 DAAA02058850 DAAA02058851

GenPept

RNA Seq Atlas

540933