InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CASK

Summary

InnateDB Gene

IDBG-637908.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASK

Gene Name

peripheral plasma membrane protein CASK

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020136

Encoded Proteins

IDBP-689978

peripheral plasma membrane protein CASK

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147044:
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:107157282-107531020

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026825

ENSBTAP00000026825

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042043	neurexin family protein binding

Biological Process

GO:0001953	negative regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0010839	negative regulation of keratinocyte proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061045	negative regulation of wound healing
GO:0070509	calcium ion import
GO:0090280	positive regulation of calcium ion import
GO:0090288	negative regulation of cellular response to growth factor stimulus

Cellular Component

GO:0005604	basement membrane
GO:0005634	nucleus
GO:0005652	nuclear lamina
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016363	nuclear matrix
GO:0045202	synapse