Bos taurus Gene: PLOD2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-638010.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | PLOD2 | ||||||||||||||
Gene Name | procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000007331 | ||||||||||||||
Encoded Proteins |
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152952:
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 1:123322467-123444003 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
Collagen formation pathway
Collagen formation pathway
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
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KEGG |
Lysine degradation pathway
Lysine degradation pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | A7MB83 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 533642 | ||||||||||||||
UniGene | Bt.39053 | ||||||||||||||
RefSeq | NM_001101149 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC151390 DAAA02002781 DAAA02002782 DAAA02002783 | ||||||||||||||
GenPept | AAI51391 | ||||||||||||||
RNA Seq Atlas | 533642 | ||||||||||||||