InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATF3

Summary

InnateDB Gene

IDBG-638097.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATF3

Gene Name

Cyclic AMP-dependent transcription factor ATF-3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008545

Encoded Proteins

IDBP-690140

Cyclic AMP-dependent transcription factor ATF-3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 16688168

[Homo sapiens] ATF3 is induced by lipopolysaccharide (LPS) and regulates TLR-stimulated inflammatory responses as part of a negative-feedback loop.

PMID 24317040

[Mus musculus] Atf3 has been identified as a high-density lipoprotein �??inducible negative regulator of macrophage activation.

PMID 26416280

[Mus musculus] Atf3 plays an important role in modulating IFN responses in macrophages by controlling basal and inducible levels of Ifnb1, as well as the expression of genes downstream of IFN signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162772:
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:72820026-72832974

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011265

ENSBTAP00000011265

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006094	gluconeogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0035914	skeletal muscle cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter