InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ITGA8

Summary

InnateDB Gene

IDBG-638143.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA8

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007602

Encoded Proteins

IDBP-690272

integrin, alpha 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077943:
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:30340780-30527982

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000039425

ENSBTAP00000039219

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001656	metanephros development
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007613	memory
GO:0030030	cell projection organization
GO:0030198	extracellular matrix organization
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042472	inner ear morphogenesis
GO:0045184	establishment of protein localization
GO:0048745	smooth muscle tissue development
GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation