InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRAF5

Summary

InnateDB Gene

IDBG-638230.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF5

Gene Name

TNF receptor-associated factor 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012020

Encoded Proteins

IDBP-690290

TNF receptor-associated factor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 11479302

[Homo sapiens] TRAF5 is a signal transducer for the TNF receptor superfamily that is involved in TNF-induced NF-kappaB activation and protection from cell death.

PMID 19017969

[Homo sapiens] TRAF5, along with other TRAFs, is recruited to many TNF-receptor (TNF-R) superfamily members and is an important modulator of the proximal signaling events that occur at the time of receptor engagement and activation. TRAF5 has been shown to be a positive regulator of a number of these receptors that are involved in T cell co-stimulation.

PMID 20161788

[Homo sapiens] TRAF5, a ubiquitin ligase, is a key molecule in the innate response against viral infection where it mediates the activation of IRF3 and NF-kappaB downstream of MAVS through the recruitment of NEMO.

PMID 23951545

[Mus musculus] The binding of MAVS to Traf2, Traf5, and Traf6 is dependent on virus infection and MAVS polymerization. The TRAF proteins promote ubiquitination that recruits IKBKG binding to the MAVS signalling complex

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082512:
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:73894532-73939371

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015940

ENSBTAP00000015940

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0016567	protein ubiquitination
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000082512

View Gene Order

ENSMUSG00000026637

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

NetPath_21

RANKL pathway

NetPath_26

TWEAK pathway

REACTOME

KEGG

hsa05222

Small cell lung cancer pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.8981

RefSeq

NM_001105340

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas