Version 5.4
Bos taurus Gene: EGLN2
Summary
InnateDB Gene IDBG-638244.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGLN2
Gene Name egl nine homolog 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017996
Encoded Proteins
IDBP-690329
EGL nine (C.elegans) homolog 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171570:
RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:50326698-50334391
Strand Forward strand
Band
Transcripts
ENSBTAT00000023945 ENSBTAP00000023945
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019826 oxygen sensor activity
GO:0031418 L-ascorbic acid binding
GO:0031545 peptidyl-proline 4-dioxygenase activity
Biological Process
GO:0001666 response to hypoxia
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0043523 regulation of neuron apoptotic process
GO:0045454 cell redox homeostasis
GO:0045732 positive regulation of protein catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000171570
View Gene Order
ENSMUSG00000058709
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_199106
Cellular response to hypoxia pathway
REACT_199108
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_199109
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
KEGG
mmu05211
Renal cell carcinoma pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A7E3S2 F1MX98
UniProt Splice Variant
Entrez Gene 536763
UniGene Bt.102303 Bt.107389
RefSeq XM_005218987
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT030693 DAAA02047091
GenPept ABS45009
RNA Seq Atlas 536763

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca