InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDE4B

Summary

InnateDB Gene

IDBG-638251.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4B

Gene Name

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008636

Encoded Proteins

IDBP-690315

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

IDBP-690317

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184588:
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:79284893-79734224

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000054382	ENSBTAP00000052598
ENSBTAT00000011390	ENSBTAP00000011390

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0001780	neutrophil homeostasis
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0030593	neutrophil chemotaxis
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0035690	cellular response to drug
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0071222	cellular response to lipopolysaccharide