Version 5.4
Bos taurus Gene: BT.104277
Summary
InnateDB Gene IDBG-638563.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.104277
Gene Name SH3 domain-containing kinase-binding protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003727
Encoded Proteins
IDBP-690640
SH3 domain-containing kinase-binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147010:
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:130459281-130711913
Strand Forward strand
Band
Transcripts
ENSBTAT00000004853 ENSBTAP00000004853
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 196 interaction(s) predicted by orthology.
Predicted by orthology
Total 196 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0016477 cell migration
Cellular Component
GO:0005911 cell-cell junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000147010
View Gene Order
ENSMUSG00000040990
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
REACTOME
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_203917
EGFR downregulation pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188194
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_189085
Disease pathway
REACT_230745
Immune System pathway
REACT_242976
Signaling by EGFR pathway
REACT_229531
Adaptive Immune System pathway
REACT_188257
Signal Transduction pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
hsa04144
Endocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
erbb1_internalization_pathway
Internalization of ErbB1
Cross-References
SwissProt
TrEMBL F1MVN9
UniProt Splice Variant
Entrez Gene 510489
UniGene Bt.104277
RefSeq NM_001128500
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02074544
GenPept
RNA Seq Atlas 510489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca