InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BAMBI

Summary

InnateDB Gene

IDBG-638629.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAMBI

Gene Name

BMP and activin membrane-bound inhibitor homolog precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003045

Encoded Proteins

IDBP-690705

BMP and activin membrane-bound inhibitor homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095739:
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:36326194-36333080

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003960

ENSBTAP00000003960

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005109	frizzled binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016477	cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032092	positive regulation of protein binding
GO:0035413	positive regulation of catenin import into nucleus
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090263	positive regulation of canonical Wnt signaling pathway