Version 5.4
Bos taurus Gene: DBR1
Summary
InnateDB Gene IDBG-638634.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DBR1
Gene Name lariat debranching enzyme
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019949
Encoded Proteins
IDBP-690713
lariat debranching enzyme
IDBP-690715
lariat debranching enzyme
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138231:
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:132002921-132014620
Strand Forward strand
Band
Transcripts
ENSBTAT00000026574 ENSBTAP00000026574
ENSBTAT00000052202 ENSBTAP00000047786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008419 RNA lariat debranching enzyme activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138231
View Gene Order
ENSMUSG00000032469
View Gene Order
Cross-References
SwissProt
TrEMBL A1L526
UniProt Splice Variant
Entrez Gene 530188
UniGene Bt.1508
RefSeq NM_001080290 XM_005201876
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT029813 DAAA02002963
GenPept ABM06079
RNA Seq Atlas 530188

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca