Bos taurus Gene: ITGA3 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-638685.3 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | ITGA3 | ||||||||||||||||||||
Gene Name | Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain | ||||||||||||||||||||
Synonyms | GAPB3 | ||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||
Ensembl Gene | ENSBTAG00000019498 | ||||||||||||||||||||
Encoded Proteins |
Integrin alpha-3Integrin alpha-3 heavy chainIntegrin alpha-3 light chain
Integrin alpha-3Integrin alpha-3 heavy chainIntegrin alpha-3 light chain
Integrin alpha-3Integrin alpha-3 heavy chainIntegrin alpha-3 light chain
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||
Summary |
[Homo sapiens] ITGA3 along with ITGB1 is a novel regulator for the recognition of bacterial lipopeptides. ITGA3/ITGB1 integrin regulates endosomal Toll-like receptor (TLR)-2/TLR1 signalling, serving as a mechanism for modulating inflammatory responses.
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Entrez Gene | |||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005884:
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 19:37198628-37231287 | ||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||
Band | |||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Cell surface interactions at the vascular wall pathway
Laminin interactions pathway
Extracellular matrix organization pathway
Basigin interactions pathway
Hemostasis pathway
Integrin cell surface interactions pathway
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KEGG | |||||||||||||||||||||
INOH | |||||||||||||||||||||
PID NCI | |||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||
NETPATH |
EGFR1 pathway
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REACTOME |
Basigin interactions pathway
Cell surface interactions at the vascular wall pathway
Integrin cell surface interactions pathway
Extracellular matrix organization pathway
Laminin interactions pathway
Hemostasis pathway
Hemostasis pathway
Cell surface interactions at the vascular wall pathway
Extracellular matrix organization pathway
Basigin interactions pathway
Laminin interactions pathway
Integrin cell surface interactions pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Hematopoietic cell lineage pathway
ECM-receptor interaction pathway
Small cell lung cancer pathway
Focal adhesion pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Hypertrophic cardiomyopathy (HCM) pathway
Pathways in cancer pathway
Dilated cardiomyopathy pathway
ECM-receptor interaction pathway
Hematopoietic cell lineage pathway
Regulation of actin cytoskeleton pathway
Small cell lung cancer pathway
Focal adhesion pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Pathways in cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
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INOH |
Integrin signaling pathway pathway
Integrin signaling pathway pathway
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PID NCI |
Beta1 integrin cell surface interactions
Reelin signaling pathway
Integrin family cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
IL23-mediated signaling events
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
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Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | F6RB56 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 508490 | ||||||||||||||||||||
UniGene | Bt.103104 | ||||||||||||||||||||
RefSeq | XM_003583574 XM_003587418 XM_005195703 XM_005220638 | ||||||||||||||||||||
HUGO | |||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | |||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | DAAA02049042 | ||||||||||||||||||||
GenPept | |||||||||||||||||||||
RNA Seq Atlas | 508490 | ||||||||||||||||||||