InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PCSK2

Summary

InnateDB Gene

IDBG-638693.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCSK2

Gene Name

neuroendocrine convertase 2 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008687

Encoded Proteins

IDBP-690788

neuroendocrine convertase 2 precursor

IDBP-690790

neuroendocrine convertase 2 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125851:
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:37812787-38051895

Strand

Forward strand

Band

Transcripts

ENSBTAT00000052049	ENSBTAP00000050841
ENSBTAT00000011451	ENSBTAP00000011451

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0007399	nervous system development
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0016540	protein autoprocessing
GO:0030070	insulin processing
GO:0034230	enkephalin processing