InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HERC2

Summary

InnateDB Gene

IDBG-638724.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HERC2

Gene Name

E3 ubiquitin-protein ligase HERC2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013916

Encoded Proteins

IDBP-690905

hect domain and RLD 2

IDBP-690909

hect domain and RLD 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128731:
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:646582-878049

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000018496	ENSBTAP00000018496
ENSBTAT00000063010	ENSBTAP00000054070

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0020037	heme binding
GO:0031625	ubiquitin protein ligase binding
GO:0032183	SUMO binding
GO:0046872	metal ion binding