Bos taurus Gene: BT.26847 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-638875.3 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | BT.26847 | ||||||||||||||||||||||||
Gene Name | linker for activation of T-cells family member 1 precursor | ||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000021249 | ||||||||||||||||||||||||
Encoded Proteins |
linker for activation of T-cells family member 1
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
Summary |
[Homo sapiens] LAT dephosphorylation in human platelets is integrin-mediated and involves PTPN1 protein tyrosine phosphatase and both PTPN1 activation and LAT dephosphorylation processes were involved in the control of irreversible platelet aggregation upon FcgammaRIIa stimulation.
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Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213658:
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 25:26120769-26125637 | ||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||
Band | |||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Homo sapiens
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH |
KitReceptor pathway
TCR pathway
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REACTOME |
Innate Immune System pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
GPVI-mediated activation cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
FCERI mediated MAPK activation pathway
TCR signaling pathway
DAP12 interactions pathway
DAP12 signaling pathway
Generation of second messenger molecules pathway
GPVI-mediated activation cascade pathway
TCR signaling pathway
Platelet activation, signaling and aggregation pathway
Adaptive Immune System pathway
Immune System pathway
Hemostasis pathway
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KEGG |
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Fc gamma R-mediated phagocytosis pathway
Fc epsilon RI signaling pathway pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Fc gamma R-mediated phagocytosis pathway
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INOH |
CD4 T cell receptor signaling pathway
CD4 T cell receptor signaling pathway
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PID NCI |
TCR signaling in naïve CD8+ T cells
TCR signaling in naïve CD4+ T cells
Signaling events mediated by PTP1B
JNK signaling in the CD4+ TCR pathway
Fc-epsilon receptor I signaling in mast cells
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Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | F1MZ60 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 514735 | ||||||||||||||||||||||||
UniGene | Bt.26847 | ||||||||||||||||||||||||
RefSeq | NM_001104978 | ||||||||||||||||||||||||
HUGO | HGNC:18874 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | DAAA02057881 | ||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | 514735 | ||||||||||||||||||||||||