InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACE2

Summary

InnateDB Gene

IDBG-638902.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACE2

Gene Name

Angiotensin-converting enzyme 2 Processed angiotensin-converting enzyme 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000034402

Encoded Proteins

IDBP-691016

Angiotensin-converting enzyme 2Processed angiotensin-converting enzyme 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22837003

[Homo sapiens] ACE2 deficiency results in increased susceptibility to intestinal inflammation induced by epithelial damage. ACE2 links amino acid malnutrition to altered gut microbiota, which leads to colitis susceptibility. (Demonstrated in mice)

PMID 22837003

[Mus musculus] Ace2 deficiency results in increased susceptibility to intestinal inflammation induced by epithelial damage. Ace2 links amino acid malnutrition to altered gut microbiota, which leads to colitis susceptibility.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130234:
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:135148996-135198057

Strand

Forward strand

Band

Transcripts

ENSBTAT00000048730

ENSBTAP00000045721

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0001948	glycoprotein binding
GO:0004175	endopeptidase activity
GO:0004180	carboxypeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008241	peptidyl-dipeptidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0003051	angiotensin-mediated drinking behavior
GO:0006508	proteolysis
GO:0009615	response to virus
GO:0032800	receptor biosynthetic process
GO:0046813	receptor-mediated virion attachment to host cell

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome