InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.48094

Summary

InnateDB Gene

IDBG-639097.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.48094

Gene Name

homeobox protein Nkx-2.2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010277

Encoded Proteins

IDBP-691217

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125820:
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:41104463-41107079

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000013574

ENSBTAP00000013574

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001159	core promoter proximal region DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0003323	type B pancreatic cell development
GO:0003326	pancreatic A cell fate commitment
GO:0003327	type B pancreatic cell fate commitment
GO:0003329	pancreatic PP cell fate commitment
GO:0006355	regulation of transcription, DNA-templated
GO:0007224	smoothened signaling pathway
GO:0007399	nervous system development
GO:0014003	oligodendrocyte development
GO:0021522	spinal cord motor neuron differentiation
GO:0021529	spinal cord oligodendrocyte cell differentiation
GO:0021530	spinal cord oligodendrocyte cell fate specification
GO:0030154	cell differentiation
GO:0031018	endocrine pancreas development
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048565	digestive tract development
GO:0048665	neuron fate specification
GO:0048708	astrocyte differentiation
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060580	ventral spinal cord interneuron fate determination