Version 5.4
| Bos taurus Gene: MGST1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-639137.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | MGST1 | ||||||||
| Gene Name | microsomal glutathione S-transferase 1 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000008541 | ||||||||
| Encoded Proteins |
microsomal glutathione S-transferase 1
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008394:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 5:93926791-93950162 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Glutathione conjugation pathway
Aflatoxin activation and detoxification pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
Aflatoxin activation and detoxification pathway
Phase II conjugation pathway
Metabolism pathway
Glutathione conjugation pathway
Biological oxidations pathway
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| KEGG |
Glutathione metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
Glutathione metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1MXY2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 493719 | ||||||||
| UniGene | |||||||||
| RefSeq | NM_001007815 XM_005206974 | ||||||||
| HUGO | HGNC:7061 | ||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02014204 DAAA02014205 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 493719 | ||||||||