Bos taurus Gene: BT.20288 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-639157.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | BT.20288 | ||||||||||||||
Gene Name | nuclear factor NF-kappa-B p100 subunit | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000006017 | ||||||||||||||
Encoded Proteins |
nuclear factor NF-kappa-B p100 subunit
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||
Summary |
[Homo sapiens] NFKB2 (p49/p100 subunit) associates efficiently with RELB and up-regulates the synthesis of NFKBIA (IKappaB-alpha).
[Homo sapiens] NFKB2 plays a key role in the regulation of RELA activation, suggesting an overlap in the function of NF-kappaB members in canonical and non-canonical pathway signalling.
[Homo sapiens] NFKB2 rearrangement gene product (p58) localizes in the nucleus to form a complex with RELA or RELB, suggesting that such NFKB2 gene rearrangement may therefore be a factor in the constitutive activation of NF-kappaB in adult T-cell leukemia (ATL), and thereby playing a role in the ATL pathogenesis.
[Homo sapiens] NFKB2 negatively regulates TCR signaling by binding with RELA, RELB, REL and NFKB1 (p50) in the cytoplasm and inhibiting these proteins from entering nucleus.
[Homo sapiens] NFKB2 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.
[Mus musculus] Bacterial cell wall glucosaminyl-muramyl dipeptides (GMDPs) bind to the transcription factor Ybx1 to upregulate Nfkb2 and Cxcr4 gene expression.
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Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077150:
This gene encodes one of the subunits of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB transcription factor complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The NFkB complex can consist of different subunits that form both homo- or heterodimers which bind specific kappa-B elements in target genes. This gene encodes the p100 subunit that is processed into the active p52 subunit. This protein can function as both a transcriptional activator and repressor, depending on its dimer partner. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, May 2012] This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 26:22891378-22898307 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 128 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH |
TNFalpha pathway
RANKL pathway
TSLP pathway
TWEAK pathway
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REACTOME |
RIP-mediated NFkB activation via ZBP1 pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Interleukin-1 processing pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
Interleukin-1 processing pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
RIP-mediated NFkB activation via ZBP1 pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG |
MAPK signaling pathway pathway
Pathways in cancer pathway
Osteoclast differentiation pathway
MAPK signaling pathway pathway
Pathways in cancer pathway
Osteoclast differentiation pathway
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INOH | |||||||||||||||
PID NCI |
IL12-mediated signaling events
Alternative NF-kappaB pathway
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Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | F6Q9X9 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 526392 | ||||||||||||||
UniGene | Bt.20288 | ||||||||||||||
RefSeq | NM_001102101 | ||||||||||||||
HUGO | HGNC:7795 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | DAAA02059000 DAAA02059001 | ||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | 526392 | ||||||||||||||