InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALDOA

Summary

InnateDB Gene

IDBG-639227.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDOA

Gene Name

fructose-bisphosphate aldolase A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012927

Encoded Proteins

IDBP-691366

fructose-bisphosphate aldolase C-A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149925:
The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:26470488-26475202

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017177

ENSBTAP00000017177

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004332	fructose-bisphosphate aldolase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0016829	lyase activity
GO:0044822	poly(A) RNA binding
GO:0070061	fructose binding

Biological Process

GO:0006000	fructose metabolic process
GO:0006096	glycolytic process
GO:0006754	ATP biosynthetic process
GO:0006941	striated muscle contraction
GO:0008360	regulation of cell shape
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0046716	muscle cell cellular homeostasis