InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.43504

Summary

InnateDB Gene

IDBG-639417.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.43504

Gene Name

MAP/microtubule affinity-regulating kinase 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002682

Encoded Proteins

IDBP-691593

MAP/microtubule affinity-regulating kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007047:
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:53330878-53379087

Strand

Forward strand

Band

Transcripts

ENSBTAT00000003476

ENSBTAP00000003476

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043015	gamma-tubulin binding
GO:0050321	tau-protein kinase activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001578	microtubule bundle formation
GO:0006468	protein phosphorylation
GO:0007399	nervous system development
GO:0016310	phosphorylation

Cellular Component

GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0015630	microtubule cytoskeleton
GO:0043005	neuron projection

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000007047

View Gene Order

ENSMUSG00000030397

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

lkb1_pathway

LKB1 signaling events

Cross-References

SwissProt

TrEMBL

F1N7E8

UniProt Splice Variant

Entrez Gene

525675

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02047351 DAAA02047352 DAAA02047353 DAAA02047354 DAAA02047355 DAAA02047356 DAAA02047357 DAAA02047358 DAAA02047359 DAAA02047360 DAAA02047361 DAAA02047362 DAAA02047363 DAAA02047364 DAAA02047365 DAAA02047366 DAAA02047367 DAAA02047368 DAAA02047369 DAAA02047370 DAAA02047371 DAAA02047372 DAAA02047373 DAAA02047374 DAAA02047375

GenPept

RNA Seq Atlas

525675