InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.64208

Summary

InnateDB Gene

IDBG-639456.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.64208

Gene Name

spectrin alpha chain, brain

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015327

Encoded Proteins

IDBP-691634

spectrin alpha chain, brain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197694:
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:99131533-99179460

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020395

ENSBTAP00000020395

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.

Predicted by orthology
Total	97 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030507	spectrin binding
GO:0046982	protein heterodimerization activity

Biological Process

Cellular Component

GO:0005916	fascia adherens
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0030018	Z disc
GO:0030863	cortical cytoskeleton
GO:0032437	cuticular plate
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome