InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ERCC1

Summary

InnateDB Gene

IDBG-639466.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERCC1

Gene Name

DNA excision repair protein ERCC-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017355

Encoded Proteins

IDBP-691633

DNA excision repair protein ERCC-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000012061:
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5\' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:53451652-53466227

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023078

ENSBTAP00000023078

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000014	single-stranded DNA endodeoxyribonuclease activity
GO:0001094	TFIID-class transcription factor binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016787	hydrolase activity
GO:0017025	TBP-class protein binding
GO:0019904	protein domain specific binding
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
GO:0000737	DNA catabolic process, endonucleolytic
GO:0001302	replicative cell aging
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006312	mitotic recombination
GO:0006949	syncytium formation
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008584	male gonad development
GO:0009650	UV protection
GO:0010165	response to X-ray
GO:0010259	multicellular organismal aging
GO:0032205	negative regulation of telomere maintenance
GO:0035166	post-embryonic hemopoiesis
GO:0035264	multicellular organism growth
GO:0036297	interstrand cross-link repair
GO:0045190	isotype switching
GO:0048468	cell development
GO:0048477	oogenesis
GO:0051276	chromosome organization

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0005737	cytoplasm