InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC40A1

Summary

InnateDB Gene

IDBG-639521.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC40A1

Gene Name

solute carrier family 40 member 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010498

Encoded Proteins

IDBP-691689

solute carrier family 40 (iron-regulated transporter), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138449:
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:6716591-6740329

Strand

Forward strand

Band

Transcripts

ENSBTAT00000048226

ENSBTAP00000045304

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005381	iron ion transmembrane transporter activity
GO:0005515	protein binding

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0003158	endothelium development
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0034755	iron ion transmembrane transport
GO:0043066	negative regulation of apoptotic process
GO:0048536	spleen development
GO:0060345	spleen trabecula formation
GO:0060586	multicellular organismal iron ion homeostasis

Cellular Component

GO:0005622	intracellular
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane