Version 5.4
Bos taurus Gene: ECHS1
Summary
InnateDB Gene IDBG-639539.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECHS1
Gene Name Enoyl-CoA hydratase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017710
Encoded Proteins
IDBP-691707
Enoyl-CoA hydratase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127884:
The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:25856475-25865594
Strand Forward strand
Band
Transcripts
ENSBTAT00000044947 ENSBTAP00000042386
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004300 enoyl-CoA hydratase activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000127884
View Gene Order
ENSMUSG00000025465
View Gene Order
Pathways
NETPATH
REACTOME
REACT_208019
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
REACT_208669
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_211406
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_225673
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_201892
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_219139
Metabolism pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_220229
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_202075
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1887
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_735
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_419
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
REACT_1697
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_1708
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_1541
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_111217
Metabolism pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_233858
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_237597
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_188937
Metabolism pathway
REACT_236353
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_261839
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_257646
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_256910
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_231111
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00650
Butanoate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa00380
Tryptophan metabolism pathway
hsa00071
Fatty acid degradation pathway
hsa00062
Fatty acid elongation pathway
hsa00310
Lysine degradation pathway
hsa00410
beta-Alanine metabolism pathway
mmu00410
beta-Alanine metabolism pathway
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00062
Fatty acid elongation pathway
mmu00310
Lysine degradation pathway
mmu00380
Tryptophan metabolism pathway
mmu00640
Propanoate metabolism pathway
mmu00650
Butanoate metabolism pathway
mmu00071
Fatty acid degradation pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Propanoate metabolism pathway
INOH website
Butanoate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
INOH website
Lysine degradation pathway
PID NCI
Cross-References
SwissProt Q58DM8
TrEMBL
UniProt Splice Variant
Entrez Gene 281748
UniGene Bt.64629
RefSeq NM_001025206
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109605 BT021569 DQ058603 DQ058610
GenPept AAI09606 AAX46416 AAY83878 AAY83884
RNA Seq Atlas 281748

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca